• 科技部計畫 (2003-至今)

    MOST Grant (2003-present)

     

    慢性疼痛與憂鬱症共病的生物機制及臨床分型:探討中樞敏感化的分子機轉 Biological mechanisms and clinical subtyping

      for comorbidity of chronic pain and depression: The molecular approach of central sensitization. (MOST 106-2314-

      B-039-027-MY3) 2019.8.1-2020.7.31 

     

    慢性疼痛與憂鬱症共病的生物機制及臨床分型:探討中樞敏感化的分子機轉 Biological mechanisms and clinical subtyping 

       for comorbidity of chronic pain and depression: The molecular approach of central sensitization. (MOST 106-2314-

      B-039-027-MY3) 2018.8.1-2019.7.31

     

    減重手術對進食行為、憂鬱、發炎及腸道微生物的影響:動物實驗與臨床醫學實證 Impacts of bariatric surgeries on

      eating behaviors, depression, inflammation, and gut microbiomes: From animal models to evidence based medicine.

      (MOST 106-2314-B-039-031) 2017.8.1- 2018.7.31

     

    慢性疼痛與憂鬱症共病的生物機制及臨床分型:探討中樞敏感化的分子機轉 Biological mechanisms and clinical subtyping

       for comorbidity of chronic pain and depression: The molecular approach of central sensitization. (MOST 106-2314-

      B-039-027-MY3) 2017.8.1- 2018.7.31

     

    Omega-3脂肪酸對急性冠狀動脈綜合症後之重鬱症雙盲安慰劑療效研究 Omega-3 fatty acids in depression of post-acute

       coronary syndrome patients: A double-blind placebo-controlled trial (MOST 106-2314-B-039-035) 2017.8.1- 2018.7.31

     

    減重手術對進食行為、憂鬱、發炎及腸道微生物的影響:動物實驗與臨床醫學實證 Impacts of bariatric surgeries on

       eating behaviors, depression, inflammation, and gut microbiomes: From animal models to evidence based medicine

      (MOST 106-2314-B-039-031) 2017.8.1-2018.7.31

     

    退黑激素受體致效劑及omega-3多元不飽和脂肪酸對節律調節及神經保護的作用:從細胞實驗、動物模型到臨床研究之探

      討 Melatoninergic agonists and omega-3 fatty acids in circadian rhythm and neuroprotection: from cellular, animal, to

      clinical research. (MOST 106-2314-B-038-049) 2017.8.1- 2018.7.31

     

    針灸療法之神經、心理及生物效應研究:以針灸療法探討憂鬱症之身心介面 Neuropsychobiology of Acupuncture: a Mind-

      Body Interface for Depression (MOST 105-2320-B-039-027)  2016.8.1-2017.7.31

     

    探索和鑒別不飽和脂肪酸之間的功能關係和相互作用以及在治療抑鬱症和神經退變性疾病中的抗炎和神經保護機制

       Exploration of Anti-Inflammatory and Neuroprotective Mechanisms by Which Different Omega-3 Fatty Acids, Alone or

      Interaction, Treat Depression and Neurodegeneration (MOST 103-2320-B-039 -041 -MY3) 2016.8.1-2017.7.31

     

    舉辦「第五屆身心介面國際研討會」The 5th MBI Symposium (104-2916-I-039-002-A1) 2015.10.20-2015.10.21 

     

    Omega-3多元不飽和脂肪酸對心血管疾病患者共患憂鬱症的雙盲療效研究(1/3) Omega-3 polyunsaturated fatty acids on

       major depressive disorder in patients with cardiovascular diseases: a double-blind placebo-controlled therapeutic trial

      (MOST 104-2314-B-039 -050 -MY3) 2015.8.1-2016.7.31

     

    Omega-3 fatty acids在憂鬱症治療的機制:由慢性壓力反應、神經新生 和發炎的關係來探討EPA及DHA的神經效應(2/3) 

       Emerging Mechanisms of Omega-3 Fatty Acids in Depression---The Effects of EPA and DHA on Chronic Stress,

       Neurogenesis and Neuroinflammation (MOST 103-2320-B-03-012-MY3) 2015.8.1-2017.7.31

     

    探討憂鬱症之炎症假說:干擾素誘發憂鬱症之基因體學研究(1/2) Pharmacogenomic approach to inflammation theory of

       depression: Genome-wide associations of interferon-α-induced depression( MOST 104-2314-B-039 -022 -MY2)

       2015.8.1- 2016.7.31

     

    N-3多元不飽和脂肪酸對於憂鬱症療效之藥物基因體學研究(2/3) Pharmacogenomics of n-3 polyunsaturated fatty acids

       treatment for major depressive disorder: Genome-wide associations. (MOST 103-2320-B-039-039-MY3) 2015.8.1 -

       2016.7.31

     

    探索和鑒別不飽和脂肪酸之間的功能關係和相互作用以及在治療抑鬱症和神經退變性疾病中的抗炎和神經保護機制

       Exploration of Anti-inflammatory and Neuroprotective Mechanisms by which Different Omega-3 Fatty Acids Treat

       Depression and Neurodegeneration (MOST 103-2320-B-039 -041 -MY3) 2015.8.1- 2016.7.31

     

    台灣精神疾病臨床試驗合作聯盟 III (TR14) Taiwan Clinical Trial Consortium for Mental Disorders (III) (MOST 104-2325-

       B-039-004) 2015.5.1- 2016.4.30

     

    臺波(PL)國合計畫-憂鬱症與n-3不飽和脂肪酸:從細胞機轉到臨床應用(2/3) Major Depression and Omega-3 Fatty Acids:

       from Cellular Mechanisms to Clinical Implications (NSC 103-2923-B-039-002 -MY3) 2015.1.1-2016.12.31

          

    N-3多元不飽和脂肪酸對於憂鬱症療效之藥物基因體學研究 Pharmacogenomics of n-3 polyunsaturated fatty acids

       treatment for major depressive disorder: Genome-wide associations.(MOST 103-2320-B-039-039-MY3)

       2014.8.1-2015.7.31

     

    不飽和脂肪酸在憂鬱症之角色探討:從分子生物學、大腦影像到行為研究 Phospholipid hypothesis of depression: From

       molecular biology, neuroimaging to behaviour (NSC101-2628-B-039-001-MY3) 2014.8.1-2015.7.31

     

    N-3多元不飽和脂肪酸對注意力缺陷/過動症兒童的雙盲療效研究 A double-blind randomized controlled trial of N-3 PUFA

       in children with attention deficit/hyperactivity disorder (MOST 103-2320-B-039-030)  2014.8.1-2015.7.31

     

    探索和鑒別不飽和脂肪酸之間的功能關係和相互作用以及在治療抑鬱症和神經退變性疾病中的抗炎和神經保護機制

       Exploration of Anti-inflammatory and Neuroprotective Mechanisms by which Different Omega-3 Fatty Acids Treat

       Depression and Neurodegeneration(MOST 103-2320-B-039-041-MY3) 2014.8.1-2015.7.31

     

    Omega-3 fatty acids在憂鬱症治療的機制:由慢性壓力反應、神經新生 和發炎的關係來探討EPA及DHA的神經效應(1/3)

       Emerging mechanisms of omega-3 fatty acids in depression: The effects of EPA and DHA on chronic stress,

       neurogenesis and neuroinflammation (MOST 103-2320-B-038 -012 -MY3) 2014.8.1-2017.7.31

     

    探索和鑒別不飽和脂肪酸之間的功能關係和相互作用以及在治療抑鬱症和神經退變性疾病中的抗炎和神經保護機制

       Exploration of Anti-inflammatory and Neuroprotective Mechanisms by which Different Omega-3 Fatty Acids Treat

       Depression and Neurodegeneration(MOST 103-2320-B-039 -041 -MY3) 2014.8.1-2015.7.31

     

    台灣精神疾病臨床試驗合作聯盟 II  Taiwan Clinical Trial Consortium for Mental Disorders II (MOST 103-2325-B-039-005)

       2014.5.1-2015.4.30

     

    Omega-3多元不飽和脂肪酸在預防孕婦憂鬱症之研究 (2/2) Omega-3 fatty acid on preventing depression in pregnant

       women (MOST 103-2911-I-039-501) 2014.3.1-2015.2.28

     

    臺波(PL)國合計畫-憂鬱症與n-3不飽和脂肪酸:從細胞機轉到臨床應用 Major Depression and Omega-3 Fatty Acids: from

       Cellular Mechanisms to Clinical Implications (NSC 103-2923-B-039-002 -MY3) 2014.1.1-2014.12.31

     

    不飽和脂肪酸在憂鬱症之角色探討:從分子生物學、大腦影像到行為研究 Phospholipid hypothesis of depression: From

       molecular biology, neuroimaging to behaviour (NSC101-2628-B-039-001-MY3) 2013.8.1-2014.7.31

     

    不飽和脂肪酸在憂鬱症之角色探討:從分子生物學、大腦影像到行為研究 Phospholipid hypothesis of depression: From

       molecular biology, neuroimaging to behaviour (NSC101-2628-B-039-001-MY3) 2012.8.1-2013.7.31

     

    從脂肪酸代謝酵素PLA2及COX2之基因多形性及基因表現探討 n-3 不飽和脂肪酸在憂鬱症之重要性(3/3) The Study of

       Polymorphisms and Expressions in Genes of Omega-3 Fatty Acid Metabolism Enzymes in the Patients with Major

       Depressive Disorder (NSC98-2320-B-038-018-MY3) 2011.8.1 -2012.7.31

     

    干擾素誘發憂鬱症之預防及治療:N-3多元不飽和脂肪酸之安慰劑雙盲對照組研究 (3/3) N-3 polyunsaturated fatty acids in

       the prevention and treatment for IFN-induced depression (NSC98-2628-B-039-020-MY3) 2011.8.1-2012.7.31

     

    抗憂鬱劑治療對身體健康之重鬱症患者的白血球與血小板交互作用之研究 The study of effects of antidepressant

       treatment on leukocyte-platelet interaction in medically health patients with major depressive disorder (NSC 98-2314-

       B-039 -011 -MY3) 2011.8.1-2012.7.31

     

    干擾素-α治療引致憂鬱症之認知及生物機制:由臨床認知功能與神經細胞機轉來探討-〈總計畫及子計畫一〉干擾素-α對C

       型肝炎病患週邊血液發炎指標之影響並探討引致憂鬱症與否之效應(3/3) Neurocognitive and Neurobiological Mechanisms

       of Interferon-Induced Depression(3/3) (NSC 100-2627-B-039-003)  2011.8.1-2012.7.31 

     

    從脂肪酸代謝酵素PLA2及COX2之基因多形性及基因表現探討 n-3 不飽和脂肪酸在憂鬱症之重要性(2/3) The Study of

       Polymorphisms and Expressions in Genes of Omega-3 Fatty Acid Metabolism Enzymes in the Patients with Major

       Depressive Disorder(2/3) (NSC99-2320-B-038-018-MY3) 2010.8.1-2011.7.31 

        

    干擾素誘發憂鬱症之預防及治療:N-3多元不飽和脂肪酸之安慰劑雙盲對照組研究 (2/3) N-3 polyunsaturated fatty acids in

       the prevention and treatment for IFN-induced depression (2/3) (NSC98-2628-B-039-020-MY3) 2010.8.1-2011.7.31

     

    抗憂鬱劑治療對身體健康之重鬱症患者的白血球與血小板交互作用之研究 The study of effects of antidepressant

       treatment on leukocyte-platelet interaction in medically health patients with major depressive disorder (NSC 98-2314-

       B-039-011-MY3) 2010.8.1-2011.7.31 

         

    國科會吳大猷先生紀念獎第三年  MOST Ta-You Wu Memorial Award (NSC 100-2628-B-039-020-MY3)

       2010.8.1-2012.7.31

     

    干擾素-α治療引致憂鬱症之認知及生物機制:由臨床認知功能與神經細胞機轉來探討-〈總計畫及子計畫一〉干擾素-α對C

       型肝炎病患週邊血液發炎指標之影響並探討引致憂鬱症與否之效應(2/3) Neurocognitive and Neurobiological Mechanisms

       of Interferon-Induced Depression(2/3) (NSC 99-2627-B-039-003)  2010.8.1-2011.7.31

     

    抗憂鬱劑治療對身體健康之重鬱症患者的白血球與血小板交互作用之研究 The study of effects of antidepressant

       treatment on leukocyte-platelet interaction in medically health patients with major depressive disorder (NSC 98-2314-

       B-039-011-MY3) 2009.8.1-2010.7.31

     

    從脂肪酸代謝酵素PLA2及COX2之基因多形性及基因表現探討 n-3 不飽和脂肪酸在憂鬱症之重要性(1/3) The Study of

       Polymorphisms and Expressions in Genes of Omega-3 Fatty Acid Metabolism Enzymes in the Patients with Major

       Depressive Disorder (NSC98-2320-B-038-018-MY3) 2009.8.1 - 2010.7.31

     

    干擾素誘發憂鬱症之預防及治療:N-3多元不飽和脂肪酸之安慰劑雙盲對照組研究 (1/3) N-3 polyunsaturated fatty acids in

       the prevention and treatment for IFN-induced depression(1/3)  (NSC98-2628-B-039-020-MY3) 2009.8.1-2010.7.31

     

    干擾素-Α治療引致憂鬱症之認知及生物機制:由臨床認知功能與神經細胞機轉來探討-〈總計畫及子計畫一〉干擾素-Α對C

       型肝炎病患週邊血液發炎指標之影響並探討引致憂鬱症與否之效應(1/3) Neurocognitive and Neurobiological Mechanisms

       of Interferon-Induced Depression (1/3) (NSC 98-2627-B-039-003 ) 2009.8.1-2010.7.31

          

    不飽和脂肪酸在C型肝炎患者接受干擾素治療誘發的身心副作用之角色探討 The Role of Polyunsaturated Fatty Acids on

       Sickness Behaviour and Depression Induced by Interferon Therapy in Patients with Hepatitis C Viral Infection

       (NSC95-2314-B-039-037-MY3)  2008.8.1-2009.7.31

     

    不飽和脂肪酸在C型肝炎患者接受干擾素治療誘發的身心副作用之角色探討 The Role of Polyunsaturated Fatty Acids on

       Sickness Behaviour and Depression Induced by Interferon Therapy in Patients with Hepatitis C Viral Infection

       (NSC95-2314-B-039-037-MY3)  2007.8.1-2008.7.31

     

    血清素回收接受器基因多型性語色氨酸氫氧脢與C型肝炎患者接受干擾素治療誘發憂鬱症的關係 Serotonin Transporter

       Gene-Linked Polymorphism Region (5HTTLPR), Tryptophan Hydroxylase-2 (TPH2) and Interferon-Induced Depressive

       Disorder in Patients with Hepatitis C Virus Infection (NSC 96-2314-B-039-020) 2007.8.1-2008.7.31

     

    不飽和脂肪酸在C型肝炎患者接受干擾素治療誘發的身心副作用之角色探討 The Role of Polyunsaturated Fatty Acids on

       Sickness Behaviour and Depression Induced by Interferon Therapy in Patients with Hepatitis C Viral Infection

       (NSC95-2314-B-039-037-MY3)  2006.8.1-2007.7.31

     

    The Effects of Comorbidity of Depression in Patients with Diabetes Mellitus by using Outpatient / Inpatient Databases

       from the National Health Insurance Claim Data in Taiwan (NSC 95-2416-H039-002) 2006.8.1-2007.7.31

     

    以功能性磁振造影評估憂鬱症病患經不同作用機轉之藥物治療前後其中樞神經精神生物機轉路徑之差異性-二年計劃

       Functional MRI for depressive patients before and after received antidepressants with different mechanism (NSC

       94-2314-B-039-011, NSC 95-2314-B-039) 2005.8.1-2007.7.31

          

    深海魚油對於大鼠在強迫游泳試驗之作用 Effect of fish oil diet on rat’s forced-swimming test( NSC 94-2314-B-039-027)

       2005.8.1-2006.7.31

     

    OMEGA-3多不飽合脂肪酸在產前及產後憂鬱症之重要性:流行病學、精神病生理學、飲食頻率、及雙盲療效研究(3/3)

       Omega-3 polyunsaturated fatty acids in women with major depressive disorders during pregnancy and afterbirth: from

       the perspectives of epidemiology, membrane psychopathophysiology, dietary differences and the double-blind placebo-

       controlled therapeutic trail (3/3) (NSC93-2320-B-039-001) 2004.8.1-2005.10.31

     

    探討精神分裂症的指紋及不對稱指標之研究 The Study of Fingerprint Fluctuating Asymmetry Criterions on Schizophrenia

       (NSC92-2320-B039-020) 2003.8.1-2004.7.31

       

    Omega-3多不飽和脂肪酸在精神分裂症之重要性:雙盲療效研究、精神病生理學及飲食頻率之探討 Omega 3 fatty acids in

       schizophrenic disorder: from the perspectives of the double-blind placebo-controlled therapeutic trail,

       membranepsychopathophysiology, and dietary differences (NSC92-2320-B-039-025) 2003.8.1-2004.7.31

     

     

    衛生福利部研究計畫(2005-至今)

    MOHW Grant (2005-present)

     

    精進臨床試驗能量及國際躍升計畫 The project for advancing performance and international competitiveness of clinical

       trials (MOHW107-TDU-B-212-123004) 2018.1.1-2018.12.31 

      

    精進臨床試驗能量及國際躍升計畫 The project for advancing performance and international competitiveness of clinical

       trials (MOHW106-TDU-B-212-113004) 2017.1.1-2017.12.31   

     

    探討多元不飽和脂肪酸做為憂鬱症分型之生物標記 Polyunsaturated fatty acids as biomarkers in classifying subtypes of

       depression (98年度-1/2)    (DOH98-TD-I-111-TM021)  2009.8.1-2009.12.31

     

    探討多元不飽和脂肪酸做為憂鬱症分型之生物標記 Polyunsaturated fatty acids as biomarkers in classifying subtypes of

       depression (DOH97-TD-I-111-TM016)  2008.5.1-2009.4.30  

     

    深海魚油對雙極型情感性精神病之保健功效:由雙盲對照試驗探討omega-3 fatty acids對改善雙極型情感性精神病之急性

       鬱期及復發預防之效果-二年計劃(2/2) The effect of fish oil in bipolar disorder: a double-blind placebo-controlled trail for

       the antidepressant and maintenance effects of in bipolar disorder (2/2) (DOH95-TD-F-113-020)  2007.1.1 ~ 2007.12.31

     

    深海魚油對憂鬱症之保健功效:由雙盲對照試驗研究來探討omega-3 fatty acids在憂鬱症之預防與治療-三年計劃(3/3)

       The Effect of Fish Oil in Major Depressive Disorder---A Double-Blind Placebo-Controlled Monotherapy Trail to

       Demonstrate the Therapeutic and Preventive Effects of Depression  (3/3) (DOH 94-TD-M-113-032) 

       2007.1.1-2007.12.31

        

    深海魚油對雙極型情感性精神病之保健功效:由雙盲對照試驗探討omega-3 fatty acids對改善雙極型情感性精神病之急性

       鬱期及復發預防之效果-二年計劃(1/2) The effect of fish oil in bipolar disorder: a double-blind placebo-controlled trail for

       the antidepressant and maintenance effects of in bipolar disorder (1/2) (DOH95-TD-F-113-020) 2006.1.1-2006.12.31

     

    深海魚油對憂鬱症之保健功效:由雙盲對照試驗研究來探討omega-3 fatty acids在憂鬱症之預防與治療-三年計劃(2/3)

       The Effect of Fish Oil in Major Depressive Disorder---A Double-Blind Placebo-Controlled Monotherapy Trail to

       Demonstrate the Therapeutic and Preventive Effects of Depression (2/3) (DOH 94-TD-M-113-032) 

       2006.1.1-2006.12.31

     

    深海魚油對憂鬱症之保健功效:由雙盲對照試驗研究來探討omega-3 fatty acids在憂鬱症之預防與治療(1/3) The Effect of

       Fish Oil in Major Depressive Disorder---A Double-Blind Placebo-Controlled Monotherapy Trail to Demonstrate the

       Therapeutic and Preventive Effects of Depression (1/3) (DOH 94-TD-M-113-032)  2005.1.1-2005.12.31

     

     

    國家衛生研究院 研究計畫 (2012-2017)

    NHRI Grant (2012-present)

     

    N-3不飽和脂肪酸做為第一線憂鬱症治療與預防:從生物標誌到臨床分型之探討 N-3 fatty acids as the first-line

       antidepressant therapy: From biomarkers to clinical subtypes (NHRI-EX106-10528NI)  2017.1.1-2017.12.31

     

    N-3不飽和脂肪酸做為第一線憂鬱症治療與預防:從生物標誌到臨床分行之探討 N-3 fatty acids as the first-line

       antidepressant therapy: From biomarkers to clinical subtypes (NHRI-EX105-10528NI) 2016.1.1-2016.12.31

     

    經顱磁刺激之神經、心理及生物效應研究:以腦磁刺激療法探討憂鬱症之身心介面 Neuropsychobiology of brain theta-

       burst stimulation: A mind-body interface for depression (NHRI-EX103-10144NI) 2014.1.1-2014.12.31 

         

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    褪黑激素致效劑及多元不飽和脂肪酸在神經元細胞SH-SY5Y的抗氧化作用:抗鬱機制的研究 (DMR-107-091)

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    不飽和脂肪酸和丁胺之抗憂鬱效果於細胞模式的後轉錄機轉研究 (CMU106-S-33) 2017.10.5-2018.7.31

     

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    發炎、疼痛與憂鬱:確立憂鬱症臨床分型隻動物模式及生物標記-發炎、疼痛與憂鬱症的分型 Subtyping in depression with

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    探討含硫胺基酸代謝於精神分裂症患者用藥及代謝症候群之相關性 (CMU97-195) 2008.8.1-2009.6.30

     

    由蛋白質體學探討C型肝炎患者接受干擾素治療誘發生病行為及憂鬱症之病理機轉 (CMU96-216) 2007.8.1-2008.7.31

     

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    外籍配偶身心健康與就醫行為之相關性研究 (CMU94-095) 2005.8.1-2006.7.31

     

     

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